Teratoma formation: A tool for monitoring pluripotency in stem cell research*

Zhang WY, de Almeida PE, Wu JC. 

Teratoma formation: A tool for monitoring pluripotency in stem cell research. 

2012 Jun 10. In: StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-. 

Available from: https://www.ncbi.nlm.nih.gov/books/NBK133287/ doi: 10.3824/stembook.1.53.1

 

 

"Unipotent stem cells are a type of stem cell that is even more specialised than multipotent stem cells. Unlike pluripotent and multipotent stem cells, which have the capacity to differentiate into several cell types, unipotent stem cells have extremely limited differentiation potential and can only develop into a single specialised cell type. They are generally associated with the specific regeneration of a type of tissue or organ. For example, in the female reproductive system, oocytes (eggs) are produced from unipotent germline stem cells in the ovaries. These cells can only differentiate into oocytes, which is a very specific and unipotent differentiation.

As a general rule, unipotent stem cells are less common than multipotent or pluripotent stem cells, and their role is often very specific in the regeneration and renewal of particular tissues. They are not as versatile as other types of stem cells, but they play a crucial role in preserving and maintaining bodily functions by regenerating essential specialised cells.

Since unipotent stem cells have a differentiation potential limited to a single cell type, specific biomarkers can be used to identify and characterise these cells;"

https://www.clinisciences.com/en/read/unipotent-stem-cells-1305.html

Unipotent stem cells Clinisciences

 

 

Stem cells: past, present, and future

Zakrzewski, W., Dobrzyński, M., Szymonowicz, M. et al. 

Stem cells: past, present, and future. Stem Cell Res Ther 10, 68 (2019).

https://doi.org/10.1186/s13287-019-1165-5